Worldwide Participation; More countries; Many scholars; Great Knowledge propagation
Nichi-In Centre for Regenerative Medicine (NCRM) announces
the
XVII Anniversary Commemorative Event,
NCRM NICHE 2022
16th October 2022
NCRM NICHE 2022 Event Summary::
NCRM NICHE is a day of commemorative events which has been conducted to celebrate the inaugural Anniversary of Nichi-In Centre for Regenerative Medicine (NCRM) (www.ncrm.org), conducted every year in the month of October.
Inaugurated on 24th of September 2005, NCRM's First Anniversary was held in 2006. NCRM NICHE was a national event until 2016, held in Chennai, India. From the XII NCRM NICHE in 2017 it is conducted in Tokyo, Japan as an International event under the sole organizing responsibility of M/s GN Corporation, Japan based on a licensing arrangement with NCRM.
NCRM NICHE provides a unique platform for inter-disciplinary interaction between students and scientists, while providing an exclusive space for researchers, entrepreneurs and innovators in this field as well. Several new collaborations and discoveries in the arena of Regenerative Medicine have seen its inception in the various NCRM NICHE events across the ages.
This year the NCRM NICHE 2022 was held as a hybrid-event successfully on the 16th of October, 2022.
The plenary session was focussed on cell therapy approach to male urethral stricture, a debilitating condition in which fibrosis in the urethra secondary to trauma or other factors including iatrogenic causes lead to fibrosis which obstructs the passage of urine.
Dr. Akio Horiguchi, an eminent Urologist & Reconstructive surgeon from the National Defence Medical College Hospital, Saitama, Japan spoke about his experience in transurethral implantation of buccal mucosal cells as a novel therapeutic approach for anterior urethral stricture. In his talk he explained how Direct vision internal urethrotomy (DVIU) is one of the most frequently performed procedures can be improved by using cell-based therapy with the buccal mucosa. He described how their team worked on reproducing the concept of Vaddi et al.'s BEES-HAUS procedure (Buccal Epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture)in rabbit model of urethral stricture proving successful engraftment. Earlier, Vaddi et al had reported the preliminary study examining the feasibility of a BEES-HAUS procedure in six male patients with recurrent bulbar urethral stricture.
References:
• Nikolavsky D, Manwaring J, Bratslavsky G et al. Novel Concept and Method of Endoscopic Urethral Stricture Treatment Using Liquid Buccal Mucosal Graft. J Urol. 2016; 196: 1788-95.
• Vaddi SP, Reddy VB, Abraham SJ. Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. Int J Urol. 2019; 26: 253-7.
• Horiguchi A, Ojima K, Shinchi M et al. Successful engraftment of epithelial cells derived from autologous rabbit buccal mucosal tissue, encapsulated in a polymer scaffold in a rabbit model of a urethral stricture, transplanted using the transurethral approach. Regenerative Therapy. 2021; 18: 127-32.
Dr. Dmitriy Nikolavsky, Director of Reconstructive Urology of Upstate Medical University,New York, USA., explained their team's stepwise accomplishment of Liquid buccal mucosal graft endoscopic urethroplasty delivered in fibrin glue in animal models and the hurdles faced in taking this concept to phase-1 human trials. Dr. Suryaprakash Vaddi, Consultant Urologist & Robotic Surgery Division,
Yashoda Hospital, Hyderabad, India who was the moderator for the session explained the journey of BEES HAUS from its concept using a novel thermo-reversible gelation polymer (TGP) for the culture-encapsulation of buccal mucosal cells to clinical translation.
The final round of Fujio Cup Quiz (FCQ) 2022 were the following presentations by the FCQ Elites who had been selected over two rounds, one preliminary round of assignments and the other pre-final round conducted online earlier.,
I. Christopher Chandra & Julianne Fay Wahyudi
Biomedical Engineering - School of Electrical Engineering and Informatics, Indonesia
Title: Exerkines – Prospective regenerative link between exercise and cardiac repair
II. Vijaya Harini S & Yoghalakshmi Nagarajan
Sri Ramachandra Institute of Higher Education and Research, India
Title: Endoplasmic Reticulum - Mitochondria Contact Sites (ERMCS) A new axis in Neuronal Regeneration
III. Jeyavarshini B & Deva Roshine
Kamaraj College of Engineering and Technology, India
Title: Gut microbiome is predominant in advancement of regenerative medicine
IV. Hasna Firdaus Aryantha& Natasya Emmanuela
School of Life Sciences and Technology, Bandung Institute of Technology, Indonesia
Title:The Potential of Integrating vs. non-integrating approaches to induced pluripotent stem cells (iPSCs) in Regenerative Medicine
V. Vivek Nayak Manibettu & Himanshu Goyal
Kasturba Medical College, Manipal, India
Title: Application of Gut Microbiome in Regenerative Medicine- A System-wise
Approach
Special Presentation:
VI. Gaurav Kansagara and Dyuti Saha
Institute for Stem Cell Science and Regenerative Medicine (inStem)
Title:
1. Hair follicle stem cells promote re-emergence of critical skin components in chronic non-healing wounds
2. Extracellular matrix protein Mindin drives fibrosis development in a mouse model of skin fibrosis.
The Fujio Cup Quiz of NCRM NICHE 2022 was won by Hasna Firdaus Aryantha & Natasya Emmanuela, Bandung Institute of Technology, Indonesia while the runner-up team was Vijaya Harini and Yoghalakshmi Nagarajan of Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
The inter-disciplinary conclave (IDC) of 2022 witnessed presentations by Prof. Schuichi Koizumi, Dept of Neuropharmacology and Glia centre,
Yamanashi University, Chuo, Japan and Dr. K.Raghavan, Consultant paediatric Neurologist,
JAICARE, Madurai, India. The session was moderated by Prof. Dr. Jurgen Hescheler,
Head, Neurophysiology, University of Cologne,Germany.
Prof. Koizumi spoke on their work on microglia’s involvement in normal and pathological brain condition such as Alexander disease etc, and strategies to manipulate their function through depletion, depletion and repopulation, and transplantation.
Dr. Raghavan spoke about their collaborative work with Japanese scientists on Prebiotics, Gut microbiome, Gut-brain-axis & the Brain, explaining their study using A.pullulans black yeast produced biological response modifier beta glucan (BRMG) on children with autism spectrum disorder (ASD) where apart from improvement in behaviour and sleep, they were we have been able to correct the gut dysbiosis evident from control of the abundance of Enterobacteriaceae using a biological response modifier beta glucan (BRMG) and increase of beneficial bacteria such as Faecalibacterium prausnitzii and Prevotella copri. Also, about the work on disease a pre-clinical study on a Stellic Animal Model (STAM) of non-alcoholic steatohepatitis (NASH) in which the AFO-202 beta glucan decreased Enterobacteriaceae, while inflammation associated bacteria such as Turicibacter and A. muciniphila were modulated best by another group which was administered A.pullulans N-163 strain produced BRMG.
References:
• Raghavan K, Dedeepiya VD, Yamamoto N, Ikewaki N, Sonoda T, Iwasaki M, Kandaswamy R, Senthilkumar R, Preethy S, Abraham SJK. Benefits of gut microbiota reconstitution by beta 1,3-1,6 glucans in subjects with autism spectrum disorder and other neurodegenerative diseases. Journal of Alzheimer's Disease.1 Jan. 2022 : 1 – 12. https://doi.org/10.3233/JAD-220388
• Preethy S, Ikewaki N, Levy GA, Raghavan K, Dedeepiya VD, Yamamoto N, Srinivasan S, Ranganathan N, Iwasaki M, Senthilkumar R, Abraham SJK. Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential for applications in human health and disease. BMJ Open Gastroenterology 2022;9:e000985. doi: 10.1136/bmjgast-2022-000985
The NCRM annual report was presented by Dr.V.Dedeepiya Devaprasad followed awarding of certificates to TPRM (Univ. of Toronto) candidates of 2021-22.
For further information kindly contact us by email to webmaster@ncrmniche.org