CAncer screening by Non-invasive Salivary Test Of Polyamines
(CAN-i-STOP)

An initiative by GN Corporation Co. Ltd., Japan

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A technology developed by Dr. Makoto Sunamura, Japan

 


Dr. Makoto Sunamura
Chief Consultant
Gastro-enterologist, Oizumi Chuo Clinic &
Visiting Faculty, Tokyo Medical University, Japan

 

For profile of Dr. Sunamura Click here

List of publications on the technology

  • 1. Tomita A,  et al. M. Effect of storage conditions on salivary polyamines quantified via liquid chromatography-mass spectrometry. Sci Rep. 2018; 8 (1 ): 12075. 
  • 2. Asai Y, et al. Elevated Polyamines in Saliva of Pancreatic Cancer. Cancers (Basel). 2018; 10 (2). Pii: E43. 
  • 3. Takayama T, et al. Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry. Clin Chim Acta. 2016; 452: 18-26. 
  • 4. Tsutsui H, et al . High-throughput LC-MS / MS based simultaneous determination of polyamines including N-acetylated forms in human saliva and the diagnostic approach to breast cancer patients. Anal Chem. 2013; 85 (24): 11835-42. 
  • 5. Ishikawa S, et al. Identification of salivary metabolomic biomarkers for oral cancer screening. Sci Rep. 2016 6: 31520.
  • 6. Sugimoto M,  et al. Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010; 6 (1): 78-95. 
  • 7. Ishikawa S, et al. Identification of salivary metabolites for oral squamous cell carcinoma and oral epithelial dysplasia screening from persistent suspicious oral mucosal lesions. Clin Oral Investig. 2018.

 


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